Neuron
ArticleVitronectin and thrombospondin promote retinal neurite outgrowth: Developmental regulation and role of integrins
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SCO-spondin-derived peptide NX210 rescues neurons from cerebral ischemia/reperfusion injury through modulating the Integrin-β1 mediated PI3K/Akt pathway
2022, International ImmunopharmacologyCitation Excerpt :During cerebral I/R in rats, inhibition of the Integrin-β1 aggravates neurobehavioral impairment and retards neurovascular regeneration [19]. In addition, thrombospondin-induced neurite outgrowth of varying neuronal cells was shown to be mediated by the activation of Integrin-β1 [20,21]. However, it is unclear whether NX210 regulates Integrin-β1/PI3K/Akt to exert neuroprotective effects after cerebral I/R.
Chondroitin sulfate-D promotes neurite outgrowth by acting as an extracellular ligand for neuronal integrin αVβ3
2019, Biochimica et Biophysica Acta - General SubjectsThrombospondin-1 Mediates Axon Regeneration in Retinal Ganglion Cells
2019, NeuronCitation Excerpt :How does neuronally expressed THBS1 promote axon regeneration? Like other extracellular matrix (ECM) molecules (e.g., laminin and vitronectin), THBS1 is an excellent substrate for neurite adhesion (Neugebauer et al., 1991; O’Shea et al., 1991). We sought to examine whether overexpressed THBS1 (i.e., THBS1 hemagglutinin [HA]) is present in the axons close to the lesion site, perhaps acting locally to promote regeneration.
Functional dissection of astrocyte-secreted proteins: Implications in brain health and diseases
2018, Progress in NeurobiologyCitation Excerpt :A study employing a TSP-1/2-knockout mouse model has shown that TSP-1 and −2 are necessary for synaptic and motor recovery after stroke (Liauw et al., 2008). Moreover, TSPs promote the neurite outgrowth of cultured neurons isolated from rat and chicken brain (DeFreitas et al., 1995; Neugebauer et al., 1991), and TSP expression is upregulated around regenerating axons following injury in mice (Moller et al., 1996). TSP-4 differs from TSP-1 and −2; it is expressed in low levels during development and at higher levels in adults.
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Present address: Fred Hutchinson Cancer Research Center, 1124 Columbia, Seattle, Washington 98104.
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Present address: Syntex Research Institute of Pharmacology, Palo Alto, California 94304