Factors influencing the release of peptides and proteins from biodegradable parenteral depot systems
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2017, International Journal of Biological MacromoleculesCitation Excerpt :It is a common phenomenon, the increasing release rate with increase in loading capacity of carboplatin (drug) [42,43] and might be due to the increasing concentration gradient of the drug between the CsNPs and the release medium [41]. Furthermore, the release rate has also been depended on various conditions such as cross-linker concentration [37], the molecular weight of a polymer, particle size [36,44] charged on drugs and polymers [44,45]. We also evaluated that carboplatin release in vitro showed a rapid initial burst, followed by slow release.
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2016, International Journal of PharmaceuticsPolymeric nanoparticles and microparticles for the delivery of peptides, biologics, and soluble therapeutics
2015, Journal of Controlled ReleaseCitation Excerpt :Release during this period is determined by the evolving pore network [109]. However, as the particle becomes more porous and the internal surface area increases, protein adsorption and desorption from the polymer play an important role in the release kinetics [103,110]. When surfactants which prevent protein adsorption to the polymer surface were included in the release media of PLGA particles containing BSA, a second burst was observed [111].
Critical attributes of formulation and of elaboration process of PLGA-protein microparticles
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Present address: Philipps-University Marburg, Dept. of Pharmaceutics, D-3550 Marburg, Germany.