Analysis of glucocorticoid-induced MYOC expression in human trabecular meshwork cells
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Research highlights
► MYOC is a delayed secondary glucocorticoid-response gene. ► A region between −2548 and −1541 on the MYOC promoter is important for the glucocorticoid response. ► MYOC mRNA is very stable and its level is increased in proportion to the time of exposure to glucocorticoid. ► MYOC expression is tissue-specific and may require tissue-specific factor(s).
Keywords
MYOC
Glaucoma
Trabecular meshwork cells
Glucocorticoid
Dexamethasone
Promoter analysis
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Present address: Laboratory of Molecular and Developmental Biology, National Eye Institute, National Institutes of Health, Bethesda, ML 20892, United States.
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