Monitoring of T-cell repertoire was useful for predicting graft-versus-host disease prognosis in a patient with chronic myelogeneous leukemia after allogeneic bone marrow transplantation
Section snippets
Discussion
During liver injury in this patient, the score of TCR-Vβ repertoires became low and TCR-Vβ reconstitution was delayed.3 Although immunosuppressive therapy resulted in limited recovery of the TCR repertoire, it was discontinued. The patient's lymphocyte counts were similar on days 19 and 82 using more than 105 CD3-positive T-cell samples. These findings suggest that the delayed recovery of TCR-Vβ was not related to the level of lymphocytes.4 In addition, delayed reconstitution of TCR-Vβ may have
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Cited by (2)
T cell regeneration after immunological injury
2021, Nature Reviews ImmunologyTRBV kinetics and its association with HLA disparity and aGVHD following allogeneic hematopoietic stem cell transplantation
2013, International Journal of Laboratory Hematology
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