Mitochondrial toxicity of triclosan on mammalian cells
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Abbreviations
EC50
concentration that diminishes the respective vitality parameter by ≥50%
ΔΨ
electric transmembrane potential
ΔΨp
membrane potential of the plasma membrane
ΔΨm
membrane potential of the mitochondrial membrane
BCF
bioconcentration factor
PBMC
monocyte-enriched peripheral blood mononuclear cells
HaCaT
a spontaneously immortalized (non-neoplastic) keratinocyte cell line
PK-15
a porcine kidney tubular epithelial cell line
MNA
a murine neuroblastoma cells
MIN-6
a murine pancreatic beta cell line
TPP+
tetraphenylphosphonium
JC-1
5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethylbenzimidazolyl-carbocyanine iodide
MIC
minimal inhibitory concentration
PI
propidium iodide
RLM
rat liver mitochondria
PN
pyridine nucleotides
Keywords
Sperm motility
Oxidative phosphorylation
Uncoupler
Glycolysis
Acidosis
Electric transmembrane potential
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These authors contributed equally to the work.
Copyright © 2015 The Authors. Published by Elsevier Inc.