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Tetrahedron Letters

Volume 52, Issue 35, 31 August 2011, Pages 4512-4514
Tetrahedron Letters

Synthesis of BCD tricyclic analogues of the novel cardiac glycoside rhodexin A

https://doi.org/10.1016/j.tetlet.2011.06.114Get rights and content

Abstract

A concise synthesis of novel cardiac glycoside analogues of rhodexin A, 14 and 24, having the BCD tricyclic system is described. The key constructive step is an inverse-electron demand Diels–Alder reaction of the silyl enol ether 4 and the 2-acetyldiene, 7 and 15.

Graphical abstract

A concise synthesis of the two BCD tricyclic analogues 14 and 24 of the cardiac glycoside rhodexin A is described.

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Acknowledgments

HVC gratefully acknowledges the National Institutes of Health for support via Grant No. GM08496.

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