Cellular adaptation to xenobiotics: Interplay between xenosensors, reactive oxygen species and FOXO transcription factors
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Graphical abstract
Abbreviations
AhR
arylhydrocarbon receptor
AIP
AhR interacting protein
ARE
antioxidant response element
ARNT
AhR nuclear translocator
bHLH
basic helix-loop-helix (DNA binding and dimerisation domain)
CAR
constitutive androstane receptor
CBP
CREB-binding protein
C. elegans
Caenorhabditis elegans
CYP
cytochrome P450
DAF-16
abnormal dauer formation 16
DBE
DAF-16 binding element (a FOXO-responsive DNA element)
DEM
diethyl maleate
EpRE
electrophile response element
FOXO
forkhead box class O
G6Pase
glucose 6-phosphatase
GCS
γ-glutamylcysteine synthetase
GST
glutathione S-transferase
HNE
4-hydroxynonenal
HNF4α
hepatocyte nuclear factor 4α
Keap-1
Kelch-like ECH-associated protein 1)
NQO1
NAD(P)H:quinone oxidoreductase-1
NOX4
NADPH oxidase 4
Nrf2
nuclear factor erythroid 2-related factor 2, also known as nuclear factor (erythroid-derived-2)-like 2
PAH
polycyclic aromatic hydrocarbons
PBRE
phenobarbital response element
PEPCK
phosphoenolpyruvate carboxykinase
PGC
PPARγ coactivator
PPAR
peroxisome proliferator-activated receptor
PI3K
phosphoinositide 3‘-kinase
PPRE
PPAR response element
PXR
pregnane xenobiotic receptor
PXRE
PXR response element
ROS
reactive oxygen species
RXR
retinoid X-receptor
SKN-1
skinhead 1
SOD
superoxide dismutase
SULT
sulfotransferase
TCDD
2,3,7,8-tetrachlorodibenzo-p-dioxin
UGT
UDP-glucuronosyl transferase
Xb
xenobiotic
XRE
xenobiotic response element
Keywords
Xenobiotic metabolism
Biotransformation of xenobiotics
Forkhead box transcription factors
Redox regulation
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© 2017 The Authors. Published by Elsevier B.V.