Original articleOptical Coherence Tomography for the Monitoring of Neovascular Age-Related Macular Degeneration: A Systematic Review
Section snippets
Methods
The target condition was nAMD of any phenotype. Eligible participants were individuals who had been treated previously for nAMD with any type of treatment and who were monitored to detect active disease. Thus, patients could have active or stable neovascular disease.
The index test was OCT, alone or in combination with other tests; that is, we included studies that used OCT alone or associated with other test or tests to detect nAMD disease activity, including any of the following: clinical
Results
We identified 4682 titles and abstracts; for 179 of these, the full text was evaluated (Fig 1). Eight were monitoring studies involving people previously diagnosed with nAMD and undergoing follow-up12, 13, 14, 15, 16, 17, 18, 19; 1 study, by Salinas-Alaman et al,17 reported results for both diagnosis and monitoring (Table 1). No studies evaluated the performance of OCT associated with other test(s). Of the 8 included studies, 4 were prospective15, 16, 17, 19 and 3 were retrospective,12, 13, 14
Discussion
Because of the burden of nAMD on patients and health care providers, an effective and efficient monitoring strategy to detect active disease is needed. The use of frequent (every 1 or 2 months) FFA is not recommended. Fundus fluorescein angiography is hampered by its cost, the fact that it is a relatively time-consuming invasive imaging technology, and its association with rare but possible risks. Current practice patterns preferred by the American Academy of Ophthalmology advise the use of FFA
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Agreement of Spectral-Domain OCT with Fluorescein Leakage in Neovascular Age-Related Macular Degeneration: Post Hoc Analysis of the HARBOR Study
2020, Ophthalmology RetinaCitation Excerpt :However, multiple clinical trials that have used OCT-guided PRN treatment regimens achieved inferior visual acuity outcomes compared with fixed monthly regimens.3,5 It is possible that the suboptimal diagnostic accuracy of OCT to detect active CNV activity may explain these differences.14 OCT angiography is an emerging imaging method to monitor neovascular AMD.18
Indications for fluorescein angiography and optical coherence tomography angiography (OCTA) in medical retina: Changes from 2015 and 2018
2020, Journal Francais d'OphtalmologieTime course of swept-source optical coherence tomography angiography findings after photodynamic therapy and aflibercept in eyes with age-related macular degeneration
2019, American Journal of Ophthalmology Case ReportsCitation Excerpt :It also is difficult to observe the detailed morphology of choroidal neovascularization (CNV) due to dye leakage.8 Optical coherence tomography (OCT) is another essential diagnostic tool for wet AMD and is indispensable for evaluating CNV activity.9 Since it is a noninvasive examination, it can be performed repeatedly.
Efficacy of nutraceutical drug in the intermediate and wet forms of age-related macular degeneration
2023, Rossiiskii Oftal'mologicheskii Zhurnal
Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.
This article is based on broader research that was funded by the National Institute for Health Research Health Technology Assessment (NIHR HTA) Programme (project no. 10/57/22) that will be published in full in a Health Technology Assessment. The Health Services Research Unit is core-funded by the Chief Scientist Office (CSO) of the Scottish Government Health and Social Care Directorates. The views and opinions expressed therein are those of the authors and do not necessarily reflect those of the HTA programme, the NIHR, the National Health Service, the Department of Health, or the CSO.
See Editorial on page 222.