Original articleCorneal Cross-Linking as a Treatment for Keratoconus: Four-Year Morphologic and Clinical Outcomes with Respect to Patient Age
Section snippets
Study Design
This was a retrospective, single-center, nonrandomized clinical study.
Population
This retrospective study included all eyes that underwent corneal CXL from April 2006 through April 2010 at the Department of Ophthalmology, Istituto Clinico Humanitas, Rozzano, Milan, Italy. The inclusion criteria for the treatment of corneal CXL were documentation of the progression of keratoconus, patients older than 9 years, signed informed consent, and corneal pachymetry results of more than 400 μm.
The preoperative
Results
Four hundred eyes of 301 patients were evaluated. The comparative functional analysis comprised the following: 49 eyes of patients between 9 and 17 years of age (12.25%), 185 eyes of patients between 18 and 29 years of age (46.25%), 115 eyes of patients between 30 and 39 years of age (28.75%), and 51 eyes of patients older than 40 years of age (12.75%). The mean age of patients was 29±10 years, and the sex distribution was 27.25% female (109 eyes). The postoperative follow-up period was
Discussion
Corneal collagen CXL modifies the natural history of progressive keratoconus by stabilizing the corneal tissue, preventing and slowing the progression of the ectatic disease.11, 12, 13, 14 The outcome of this procedure was stratified in this retrospective study according to age. Because keratoconus in children is more aggressive,9 pediatric patients were evaluated more frequently than adults. The availability of an extended 48-month follow-up allowed for extensive data collection aimed at
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2023, American Journal of OphthalmologyBelin ABCD Progression Display Identifies Keratoconus Progression Earlier Than Conventional Metrics
2022, American Journal of OphthalmologyCitation Excerpt :The ideal timeframe within which to evaluate a KC progression criterion is also not clear. Kmax (often 1-D or 1.5-D increase) is the most commonly adopted parameter for progression detection in the published literature.12-18 The lowest thresholds were reported by Soeters and associates,19 as an increase of ≥0.5 D in Kmax, Kmean, and topographic cylinder values, which is relatively more stringent than the threshold values used frequently in the literature and the clinics.
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2024, International Ophthalmology
Manuscript no. 2012-143.
Financial Disclosure(s): The author(s) have made the following disclosure(s):
Paolo Vinciguerra - Consultant - Nidek and Oculus.