Multimodal imaging of subventricular zone neural stem/progenitor cells in the cuprizone mouse model reveals increased neurogenic potential for the olfactory bulb pathway, but no contribution to remyelination of the corpus callosum
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Abbreviations
AP
antero-posterior
APC/CC1
adenomatous polyposis coli
BG
background
BLI
bioluminescence imaging
CC
corpus callosum
CNS
central nervous system
DV
dorso-ventral
EAE
experimental auto-immune encephalomyelitis
eGFP
enhanced green fluorescent protein
EWD
error weighted difference
fLuc
firefly luciferase
GE
gradient echo
GFAP
glial fibrillary acidic protein
IBA1
ionized calcium binding adaptor molecule
La
lateral
LVv
lentiviral vector
MBP
myelin basic protein
mIPs
minimum intensity projections
MPIO
micron-sized iron oxide particles
MRI
magnetic resonance imaging
MS
multiple sclerosis
NeuN
neuronal nuclear antigen
NSPC
neural stem progenitor cell
OB
olfactory bulb
p75NTR
p75 neurotrophin receptor
p.i.
post-injection
PBS
phosphate buffered saline
PC
positive control
PLL
poly-l-lysine
RF
radio-frequency
RMS
rostral migratory stream
ROI
region of interest
sCC
splenium of the corpus callosum
SVZ
subventricular zone
VOI
volume of interest
Keywords
Neural stem cell
Cuprizone
Migration
Remyelination
Magnetic resonance imaging
Bioluminescence imaging
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Both authors contributed equally to this study.
Copyright © 2013 The Authors. Published by Elsevier Inc.