Distinct functional connectivity associated with lateral versus medial rostral prefrontal cortex: A meta-analysis
Research Highlights
►This study reports a meta-analysis of 162 neuroimaging experiments ►We identified activations both inside and outside rostral prefrontal cortex (RoPFC) ►Distinct brain regions were co-activated with lateral versus medial RoPFC ►These effects were strongly influenced by the type of task being performed
Section snippets
Study selection
The present study required a database of activation peaks within RoPFC from previous functional neuroimaging studies. Additionally, for each contrast producing an activation peak within RoPFC we recorded the set of activation peaks outside RoPFC that were also reported. All studies from the earlier meta-analysis of RoPFC activations by Gilbert et al. (2006c) were included in the present database, so long as they also reported at least one activation peak outside RoPFC (102 studies; 124
Results
A list of all additional contrasts that were included in the present study but not Gilbert et al. (2006c) is provided in Table 1. In addition, Table 2 provides a breakdown of the full sample of RoPFC and extra-RoPFC activations included in the present study, according to task category.
Discussion
This study investigated functional connectivity associated with different subregions within RoPFC, by investigating co-activations between particular areas inside and outside RoPFC across a database of neuroimaging studies. There was no evidence for distinct connectivity associated with left versus right RoPFC, superior versus inferior RoPFC, or rostral versus caudal RoPFC. However, there were clear differences between lateral and medial RoPFC, such that knowledge of the extra-RoPFC activation
Acknowledgments
SJG was supported by a Royal Society University Research Fellowship; EV was supported by the Fondation Bettencourt Schueller.
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