Changing channels: An fMRI study of aging and cross-modal attention shifts
Section snippets
Participants
Ten older adults (six females, four males, age range: 65 to 89 years; mean = 70.7 ± 7) and 10 younger adults (six females, four males, age range 18 to 41 years; mean = 27.9 ± 8) were recruited from the community for this study. All participants were right handed, had normal or corrected vision, and had no reported history of major medical illness, neurological or psychiatric disorder, head trauma, or substance abuse. One of the older adults was being treated with an antidepressant medication at
Behavioral findings
The group mean percent correct target detection and response time results from the three AV task conditions are shown in Fig. 2. There were no statistically significant differences between groups in target detection accuracy, although the older adult group accuracy was numerically lower than the younger adult group, particularly in the two focus attention conditions. Both the older and younger adult groups were more accurate in visual target detection than auditory target detection across the
Discussion
The most striking age-related differences in BOLD responses from this study were bilateral frontal and parietal regions of significantly increased activation in older adults during both focus and shift tasks. Considered separately, results from the focus attention tasks are consistent with a number of studies reporting that older adults typically produce more widespread activation than younger adults when task performance is similar. Quite often, this is interpreted as evidence that older
Summary and conclusions
Our data show that, in healthy, cognitively intact older adults, there are processing inefficiencies associated with visual, auditory, and cross-modal attention. Older adults in this study performed as well as the younger adults, but with striking age-related differences in BOLD responses. While younger adults showed succinct and focal regional activations associated with attention and sensory processing, older adults showed significantly larger and more widespread activation in these same
Acknowledgments
This research was supported by funding awarded to J.T. from the U.S. National Institutes of Health, National Institute on Aging, 5RO1-AG18030.
References (42)
- et al.
Life span changes in electrophysiological measures of inhibition
Brain Cogn.
(1996) - et al.
“Mini-mental state”: a practical method for grading the cognitive state of patients for the clinician
J. Psychiat. Res.
(1975) - et al.
Working memory, comprehension, and aging: a review and a new view
Psychol. Learn. Motiv.
(1988) - et al.
Under-recruitment and nonselective recruitment: dissociable neural mechanisms associated with aging
Neuron
(2002) - et al.
Adult age differences in regional cerebral blood flow during visual world identification: evidence from H215O PET
NeuroImage
(1996) - et al.
Attentional control in the aging brain: insights from an fMRI study of the stroop task
Brain Cogn.
(2002) - et al.
Frontal circuitry degradation marks healthy adult aging: evidence from diffusion tensor imaging
NeuroImage
(2005) - et al.
Auditory–visual speech perception examined by fMRI and PET
Neurosci. Res.
(2003) - et al.
Linguistic processing in visual and modality-nonspecific brain areas: PET recordings during selective attention
Brain Res. Cogn. Brain Res.
(2004) - et al.
Age-related changes in processing auditory stimuli during visual attention: evidence for deficits in inhibitory control and sensory memory
Psychol. Aging
(1999)
Human temporal lobe activation by speech and nonspeech sounds
Cereb. Cortex
Task-independent and task-specific age effects on brain activity during working memory, visual attention and episodic retrieval
Cereb. Cortex
Prefrontal deficits in attention and inhibitory control with aging
Cereb. Cortex
Software tools for analysis and visualization of fMRI data
NMR Biomed.
Real-time 3D image registration for functional MRI
Magn. Reson. Med.
CVLT-II, California Learning Test
General and task-specific frontal lobe recruitment in older adults during executive processes: an fMRI investigation of task-switching
NeuroReport
Electrophysiological Evidence for Central Inhibitory Deficits in Old Age
PET activation of posterior temporal regions during auditory word presentation and verb generation
Cereb. Cortex
Improved assessment of significant activation in functional magnetic resonance imaging (fMRI): use of a cluster-size threshold
Magn. Reson. Med.
Auditory selective attention in young and elderly adults: the selection of single versus conjoint features
Psychophysiology
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