Association analysis of brain-derived neurotrophic factor (BDNF) gene 196 A/G polymorphism with Alzheimer's disease (AD) in mainland Chinese
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Acknowledgement
This study was supported by grant 99-699 from the China Medical Board of New York.
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Association between the Val66Met polymorphism (rs6265/G196A) of the BDNF gene and cognitive performance with SSRI use in Arab Alzheimer's disease patients
2021, Saudi Pharmaceutical JournalCitation Excerpt :Therefore, individuals with the A allele (Met) can expect to show clinically significant memory impairment within 3 years, whereas BDNF G allele (Val) individuals did not show a similar degree of impairment until 10 years later (Lim et al., 2015). Additionally, research findings broadly support the work of other studies in this area linking the BDNF Val66Met polymorphism and cognitive performance in antipsychotic-naïve patients with schizophrenia (Bian et al., 2005). Regarding the association of age and allele distribution, there were no significant associations with aging changes.
Female-specific effect of the BDNF gene on Alzheimer's disease
2017, Neurobiology of AgingCitation Excerpt :As a result, a total of 26,958 AD cases and 46,941 controls were analyzed (Supplementary Table S2) (Akatsu et al., 2006; Bagnoli et al., 2004; Bian et al., 2005; Bodner et al., 2005; Boiocchi et al., 2013; Borroni et al., 2012; Combarros et al., 2004; Cozza et al., 2008; Desai et al., 2005; Feher et al., 2009; Forero et al., 2006; Fukumoto et al., 2010; Giedraitis et al., 2009; He et al., 2007; Huang et al., 2007; Lambert et al., 2013; Lee et al., 2005; Li et al., 2005, 2008; Matsushita et al., 2005; Nishimura et al., 2005; Pivac et al., 2011; Reiman et al., 2007; Saarela et al., 2006; Sonali et al., 2013; Tsai et al., 2006; Ventriglia et al., 2002; Vepsalainen et al., 2005; Vieira et al., 2015; Yu et al., 2008; Zhang et al., 2006). For gender-specific analysis, 3737 AD cases and 3744 controls for females and 2101 AD cases and 2477 controls for males from 16 previous studies with gender information (Akatsu et al., 2006; Bian et al., 2005; Boiocchi et al., 2013; Combarros et al., 2004; Desai et al., 2005; Forero et al., 2006; Fukumoto et al., 2010; He et al., 2007; Lee et al., 2005; Li et al., 2005; Matsushita et al., 2005; Nishimura et al., 2005; Pivac et al., 2011; Saarela et al., 2006; Tsai et al., 2006; Yu et al., 2008) and the current Han Chinese data were considered (Supplementary Table S3). Meta-analysis was performed using the STATA version 13 (Stata Corporation, College Station, TX, USA) under the random-effect model if there was a significant heterogeneity (I2 >50%) or under the fixed-effect model when I2 <50%.
Reprint of: Effects of BDNF polymorphisms on brain function and behavior in health and disease
2012, Brain Research BulletinEffects of BDNF polymorphisms on brain function and behavior in health and disease
2011, Brain Research BulletinBrain derived neurotrophic factor Val66Met polymorphism and psychotic symptoms in Alzheimer's disease
2011, Progress in Neuro-Psychopharmacology and Biological Psychiatry