Molecular Cell
Volume 50, Issue 2, 25 April 2013, Pages 212-222
ArticleSignaling Pathways Differentially Affect RNA Polymerase II Initiation, Pausing, and Elongation Rate in Cells
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Graphical Abstract
Highlights
► Pol II rates vary by 4-fold between genes, cell types, and induction conditions ► Rates correlate strongly with gene expression but weakly with nucleosome occupancy ► Rate variation has important consequences for mRNA and lncRNA production ► E2 signaling stimulates Pol II initiation; TNF-α signaling reduces Pol II pause time
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Present address: Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
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