Short communicationAmbient glucose concentration and gene expression in Plasmodium falciparum
References (30)
- et al.
Hypoglycaemia in African children with severe malaria
Lancet
(1987) - et al.
The pathophysiology of malaria
Adv. Parasitol.
(1992) - et al.
Hypoglycaemia in severe falciparum malaria
Trans. R. Soc. Trop Med. Hyg.
(1988) - et al.
Regulation of infectivity of Plasmodium to the mosquito vector
Adv. Parasitol.
(1996) Plasmodium falciparum phosphoenolpyruvate carboxykinase is developmentally regulated in gametocytes
Mol. Biochem. Parasitol.
(2000)- et al.
Alpha-tubulin II is a male-specific protein in Plasmodium falciparum
Mol. Biochem. Parasitol.
(1992) Ubiquitin enters the new millennium
Mol. Cell
(2001)The ubiquitin-proteasome proteolytic pathway
Cell
(1994)RNA helicase participates in the editing game
Neuron
(2000)- et al.
The mle(napts) RNA helicase mutation in drosophila results in a splicing catastrophe of the para Na+ channel transcript in a region of RNA editing
Neuron
(2000)
Cloning the P. falciparum gene encoding PfEMP1, a malarial variant antigen and adherence receptor on the surface of parasitized human erythrocytes
Cell
Switches in expression of Plasmodium falciparum var genes correlate with changes in antigenic and cytoadherent phenotypes of infected erythrocytes
Cell
The large diverse gene family var encodes proteins involved in cytoadherence and antigenic variation of Plasmodium falciparum-infected erythrocytes
Cell
Cell signaling can direct either binary or graded transcriptional responses
EMBO J.
Acute glucose starvation activates the nuclear localization signal of a stress-specific yeast transcription factor
EMBO J.
Cited by (30)
The many paths to artemisinin resistance in Plasmodium falciparum
2023, Trends in ParasitologyMalaria parasites do respond to heat
2022, Trends in ParasitologyCitation Excerpt :This opened a debate [6] that was settled by recent studies unambiguously showing that malaria parasites can produce directed transcriptional responses when exposed to some specific external conditions. Here, we will describe only three well-defined examples of directed transcriptional responses (Figure 1), but many other studies have reported transcriptional changes after exposing parasites to different stress conditions, such as restriction of specific nutrients or exposure to drugs [30–35]. However, in many cases, the transcriptional changes occurred in genes involved in processes unrelated to protection from the stress condition and it was impossible to distinguish between authentic transcriptional responses and changes in transcript levels attributable to parasite death or growth arrest.
Disease specific modules and hub genes for intervention strategies: A co-expression network based approach for Plasmodium falciparum clinical isolates
2015, Infection, Genetics and EvolutionEntamoeba histolytica adaptation to glucose starvation: A matter of life and death
2014, Current Opinion in MicrobiologyCitation Excerpt :Evidences are accumulating that glucose starvation triggers the stage conversion of E. histolytica, E. invadens, and Acanthamoelba castellanii to the environmentally resistant cyst stage (Figure 1, Table 2) [47•,48,49•,50•]. Glucose starvation is also a signal for T. cruzi epimastigotes to extend their flagellum [51•] and gametocytogenesis in P. falciparum [45•]. One of the cell's response to glucose starvation is a massive reduction in cellular energy levels [19].
Adaptive responses to glucose restriction enhance cell survival, antioxidant capability, and autophagy of the protozoan parasite Trichomonas vaginalis
2014, Biochimica et Biophysica Acta - General SubjectsCitation Excerpt :GR is a metabolic stress that has been studied in other protists and, in some cases, is associated with pathogenesis. For instance, PfEMP (var) genes, key molecules in malaria pathogenesis, are upregulated upon GR [13]. Additionally, GR induces the differentiation of trophozoites into cysts in Entamoeba invadens [14] and boosts Entamoeba histolytica virulence [15,16].
Transcript Level Responses of Plasmodium falciparum to Antimycin A
2012, ProtistCitation Excerpt :A large proportion of regulated genes belonged to large gene families encoding exported proteins and surface antigens. The bulk regulation of genes belonging to large, co-expressed, multi-membered gene families has also been a feature of transcriptional responses of Plasmodium to a number of other stimuli (Clark et al. 2008; Fang et al. 2004) and is likely to represent a general rather than drug-specific response. We observed such a response in Plasmodium upon treatment of parasites with the apicoplast inhibitor thiostrepton (Tarr et al. 2011).