Clinical and laboratory observationThe Role of Inter-Alpha Inhibitor Proteins in the Diagnosis of Neonatal Sepsis
Section snippets
Methods
This study was conducted in the neonatal intensive care unit of Women & Infants' Hospital of Rhode Island between August 2003 and January 2004. Residual blood samples of neonates who were examined for suspected sepsis were collected. An evaluation for neonatal sepsis was done at the discretion of the neonatal providers for a variety of reasons, including maternal risk factors and signs of neonatal sepsis. Routine sepsis evaluations included a full blood count, platelet count, and blood culture.
Results
A total of 573 neonates were examined for sepsis, 45 of whom had blood culture-proven sepsis (7.5%). The identified bacteria included Staphylococcus aureus (n = 2), group B Streptococcus (n = 2), Escherichia coli (n = 5), Citrobacter species (n = 2), Enterococcus fecalis (n = 4), Klebsiella species (n = 2), coagulase-negative Staphylococcus (n = 13), other gram-positive cocci (n = 9), and Candida species (n = 7). Patients in the septic group had a lower gestational age compared with patients in
Discussion
The IaIp family is a group of plasma-associated serine protease inhibitors synthesized mainly in the liver.9 In adult patients with sepsis, plasma levels are significantly decreased (by 20%-90%) and inversely correlated with unfavorable outcome.7 In neonates, we previously studied a cohort of newborn infants with a gestational age between 24 and 42 weeks and found the circulating concentration of IaIp to be endogenously produced independent of gestational age, independent of postnatal age, and
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2022, Pharmacology and TherapeuticsCitation Excerpt :TSG-6 levels in synovial fluid correlate with disease progression in patients with osteoarthritis (Wisniewski et al., 2014). Finally, there is a wealth of literature suggesting that circulating levels of IαI are associated with survival in human infections/inflammatory diseases like severe sepsis in adults, necrotizing enterocolitis in newborns and severe dengue in children (Baek et al., 2003; Chaaban et al., 2009; Koraka et al., 2010; Lim et al., 2003; Opal et al., 2007). In this chapter we will briefly summarize established applications of HA in clinical medicine.
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Lim holds a significant interest in Prothera Biologics, which supported these studies by performing the IaIp assays. None of the other authors declare conflicts of interest