Original articleMetabolic Syndrome in Childhood Predicts Adult Metabolic Syndrome and Type 2 Diabetes Mellitus 25 to 30 Years Later
Section snippets
Methods
The PFS was a 25- to 30-year follow-up of student- and parent-participants in the Cincinnati Clinic of the National Institutes of Health–National Heart Lung and Blood Institute LRC Prevalence Program (1972-1978), a multi-stage survey of lipids and other cardiovascular disease risk factors.13, 14, 15 In 1973-1976, the LRC enrolled students in grades 1 to 12 of the public and parochial schools in the Princeton School District and a random sample of their parents. The PFS was conducted to
Results
The ethnic composition of the 814 members in the analysis cohort (28% black, 72% white) was similar to that in the total school population at the LRC Study 25 to 30 years earlier (27% black, 73% white); the proportion of females at follow-up (55%) was higher than in LRC (47%). At the LRC, the cohort ranged in age from 5 to 19 years, with a mean of 12.8 years (Table I). The mean BMI in the students was 19.8 kg/m2, and 18.2% were at or above the CDC 2000 age-specific 85th percentile (at risk of
Discussion
In this prospective follow-up study of former students from the Princeton LRC Study, children with the cluster of factors defined as pediatric metabolic syndrome were more likely than their peers to have T2DM 25 to 30 years later as adults. Pediatric metabolic syndrome and a positive parental history of T2DM were major, independent predictors of adult diabetes in the cohort, and there was a suggestion (P = .08) that having both factors may have a synergistic effect. Black men and women had
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