Reviews and feature articleAffirmation of the adoration of the vagi and role of tiotropium in asthmatic patients
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Anti-muscarinic drugs as preventive treatment of exercise-induced bronchoconstriction (EIB) in children and adults
2020, Respiratory MedicineCitation Excerpt :With the discovery of atropine, a potent competitive inhibitor of acetylcholine at postganglionic muscarinic receptors, and more importantly with the demonstration of the importance of the parasympathetic nervous system in bronchoconstriction, renewed interest has been placed on the potential value of antimuscarinic agents in asthma and EIB [45]. Vagal innervation is considered as a major determinant of airway tone and represents the reversible component of airflow obstruction [46]. An up-regulated release of acetylcholine (ACh) causes an increased bronchial tone, bronchial hyperresponsiveness and reflex bronchoconstriction, thus leading to the narrowing of the airways.
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2017, Clinical and Molecular Allergy
Disclosure of potential conflict of interest: A. F. Gelb has consultant arrangements with AstraZeneca; has received grants from Boehringer Ingelheim, GlaxoSmithKline, and Pearl Therapeutics/AstraZeneca; and has received payment for lectures from Boehringer Ingelheim and AstraZeneca. J. A. Nadel declares that he has no relevant conflicts of interest.