Immunity
Volume 33, Issue 6, 14 December 2010, Pages 890-904
ArticleFoxo Transcription Factors Control Regulatory T Cell Development and Function
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Graphical Abstract
Highlights
► Foxo1 controls Treg cell development and function ► Foxo1 directly controls expression of the Ctla4 gene ► In the absence of Foxo1, TGF-β causes T cells to assume a Th1 cell phenotype ► Double deficiency in Foxo1 and Foxo3 causes florid and pathologic autoimmunity
Cited by (0)
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These authors contributed equally to this work
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Present address: Centre d'Immunologie de Marseille Luminy, CNRS-INSERM-Université de la Méditerranée, Campus de Luminy, Case 906, 13288, Marseille Cedex 09, France
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Present address: Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA
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Present address: Institut für Physiologie, Universität Duisburg-Essen, D-45122 Essen, Germany
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