International Journal of Radiation Oncology*Biology*Physics
Poster Viewing AbstractRepeat Stereotactic Radiosurgery (SRS) for Brain Metastases Locally Recurrent Following Initial SRS
Section snippets
Purpose/Objectives
Local failure (LF) of brain metastases (BM) after initial stereotactic radiosurgery (SRS) may be treated with whole brain radiation therapy (WBRT). We report the outcomes for patients treated by repeat SRS after LF of BM, deferring WBRT.
Materials/Methods
In a retrospective review of SRS for BM from 2006 - 2013, we identified a cohort of 19 patients with 27 lesions treated with repeat SRS after LF following initial SRS (15 had SRS only and 12 had resection followed by SRS cavity boost). Among these 19 patients there were 60 courses of SRS for 139 BM (112 as primary treatment and 27 with repeat SRS). SRS was delivered in 1-5 fractions; dose was converted to SFED (single fraction equivalent dose with alpha/beta = 10). Kaplan-Meier rates of overall
Results
The median clinical follow-up was 12.3 months (0 - 48 months). For the 27 recurrent metastases, initial SRS targeted a median tumor volume of 1.29 cc (range 0.04 - 11.8 cc) to a median SFED of 22 Gy10 (16 - 24 Gy10). Median volume was 6.6 cc (0.11 - 31.4 cc) at the second course to a median SFED of 17.3 Gy10 (14.5 - 24 Gy10). At retreatment, 12 metastases were treated in 1 fraction (median 20 Gy, range 16-24 Gy), 1 in 2 fractions (22 Gy), 10 in 3 fractions (median 24 Gy, range 21-27 Gy), and 4
Conclusions
For BM locally recurrent following initial SRS, repeat SRS with deferral of WBRT is a treatment option with acceptable rates of local control and toxicity.
References (0)
Cited by (0)
Author Disclosure: P. Jayachandran: None. D. Shultz: None. L. Modlin: None. R. von Eyben: None. I.C. Gibbs: None. S. Chang: None. G. Harsh: None. G. Li: None. J. Adler: None. S.L. Hancock: None. S.G. Soltys: None.