Assessment of adjuvantation strategy of lipid squalene nanoparticles for enhancing the immunogenicity of a SARS-CoV-2 spike subunit protein against COVID-19
Graphical abstract
Lipid squalene nanoparticles (SQ@NPs) play a crucial role in the immunogenicity of the SARS-CoV-2 spike subunit protein against COVID-19. In a mouse model, we found that one dose of the S-protein with SQ@NPs works as well as two doses of the S-protein alone without compromising safety aspects following i.m. injection. These results pave the way for optimal vaccine formulations against COVID-19.
Keywords
COVID-19 vaccine
Immunomodulation
Lipid squalene nanoparticles
Single injection
Vaccine adjuvant
Cited by (0)
- 1
These authors contributed equally to this work.
© 2021 Elsevier B.V. All rights reserved.