International Journal of Oral and Maxillofacial Surgery
Clinical PaperHead and Neck OncologyClinicopathological study of distant metastases of salivary adenoid cystic carcinoma
Section snippets
Materials and methods
From 1963 to December 2009, 613 patients with SACC were admitted to the study institution. Among them, 467 patients (76.2%) were given follow-up. The follow-up period, defined as the period from the time of diagnosis of SACC to the time of last data collection or of the patient's death, ranged from 6 months to 32 years (median 12 years). The diagnosis of distant metastasis was confirmed by the histopathological examination of samples obtained by metastasectomy or by detection of metastasis by
General clinical data
Of the 467 patients with SACC who had available clinicopathological and follow-up information, 210 (45.0%) were male and 257 (55.0%) were female. Their ages ranged from 16 to 80 years, with a median age of 47 years. Two hundred and thirty-two patients (49.7%) had SACC of the minor salivary glands and 235 patients (50.3%) had SACC of the major salivary glands.
Distant metastasis rate and sites
One hundred and forty-five patients (31.0%) had distant metastasis among the 467 SACC patients with follow-up. The lung was the
Discussion
SACC is characterized by the persistent and indolent growth of the primary tumours and a high incidence of hematogenous metastasis, which ranges from 8.5% to 58.8%.1, 2, 3, 4, 5, 6, 7, 8 The lung is the predominant anatomical site of distant metastasis. However, SACC can also metastasize to bone, liver, the cerebrum, and to multiple organs.1, 3, 6, 9, 10, 11 van der Wal et al. reported that 28 of 51 patients with SACC developed distant metastasis, an incidence of 54.9%. Among those 28 patients,
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