Original contributionsMCL-1 expression in B-cell non-Hodgkin’s lymphomas
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B-cell non-Hodgkin’s lymphomas
The study group included 151 B-cell lymphomas accessioned at The University of Texas M. D. Anderson Cancer Center between 1981 and 2000. The diagnosis of these tumors was based on morphological and immunohistological criteria according to the World Health Organization (WHO) classification.21 The study group included 38 cases of mantle cell lymphoma, 31 diffuse large B-cell lymphoma, 27 follicular lymphoma (eight grade 1, ten grade 2, nine grade 3), 14 small lymphocytic lymphoma/chronic
MCL-1 protein expression in B-cell lymphomas
Among low-grade B-cell neoplasms, MCL-1 was expressed in 4 of 5 (80%) nodal and splenic marginal zone B-cell lymphoma, 4 of 11 (36%) extranodal marginal zone B-cell lymphoma of MALT type, 13 of 38 (34%) mantle cell lymphoma, 4 of 14 (29%) small lymphocytic lymphoma/chronic lymphocytic leukemia, and 1 of 6 (17%) lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia (Table 1; Fig 1). The staining intensity of MCL-1 in these tumors was weak, with relatively low percentages (10%-50%) of
Discussion
In this study, we analyzed MCL-1 expression in a series of low- and high-grade B-cell non-Hodgkin’s lymphomas of various types. MCL-1 was more frequently expressed in high-grade (88%) compared with low-grade (37%) lymphomas (P < 0.0001). In addition, MCL-1 expression was present in a significantly higher proportion of cells and was of stronger intensity in high-grade compared with low-grade B-cell lymphomas. These findings agree with 3 other studies that detected MCL-1 in high-grade B-cell
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