Short reportA bioactive biflavonoid from Campnosperma panamense
Section snippets
Plant
Campnosperma panamense Standl. (Anacardiaceae) leaves collected in May 2000 from Department del Valle, Colombia and identified by Dr. Robert T. Gonzalez, University del Valle. A voucher specimen (BW067) has been deposited in the Herbarium of the Universidad del Valle, Cali (CUVC).
Uses in traditional medicine
No medicinal use has been reported for this species, but several Anacardiaceae are used traditionally as antiplasmodial in South America [1]. The tree is used as a commercial source of timber on the Pacific coast of Colombia [2]. The antimalarial activity of leaf extract has been previously shown [3].
Previously isolated classes of constituents
No phytochemical study has yet been reported for C. panamense. Lanaroflavone has been previously reported from Lanaria lanata and Ouratea semiserrata [4], [5].
Tested materials
Lanaroflavone 1 (4‴,5,5ʺ,7,7ʺ-pentahydroxy-4′,8ʺ-biflavonyl ether) (6.9 mg from 140 g of dry plant material).
Studied activity
Antiplasmodial activity was evaluated following the microculture radioisotope technique [6] modified by Ridley [7], while leishmanicidal activity was evaluated using the axenic amastigote assay [8], [9]. Antitrypanosomial activity was evaluated by colorimetric reaction (β-galactosidase/CPRG-Nonidet) using trypomastigotes of Trypanosoma cruzi Tulahuen strain C2C4 containing the β-galactosidase (Lac Z) gene [10].
Results
Reported in Table 1.
Conclusion
Lanaroflavone exhibited good antiplasmodial activity in vitro against Plasmodium falciparum K1 chloroquine-resistant strain and moderate leishmanicidal activity against L. donovani amastigotes, but did not show antitrypanosomial activity.
Aknowledgments
The authors want to thank Vanessa Douville for technical assistance and the ECOS/ICFES/COLCIENCIAS/ICETEX program for financial support.
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