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A meta-analysis of neurocognition in youth with familial high risk for bipolar disorder

Published online by Cambridge University Press:  23 March 2020

E. Bora  and
A. Özerdem
E. Bora*
Affiliation:
Dokuz Eylül University, Faculty of Medicine, Department of Psychiatry, Izmir, Turkey Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Carlton South, 3053Victoria, Australia
A. Özerdem
Affiliation:
Dokuz Eylül University, Faculty of Medicine, Department of Psychiatry, Izmir, Turkey Dokuz Eylul University, Health Sciences Institute, Department of Neurosciences, Izmir, Turkey
*
* Corresponding author. Dokuz Eylul Universitesi Tip Fakultesi, Psikiyatri Anabilimdali, Mithatpaşa cad. no 1606 inciralt. yerleşkesi 35340 Balçova/İzmir. Tel. : +90 232 412 22 22. E-mail addresses:emre.bora@deu.edu.tr, ibora@unimelb.edu.au (E. Bora).
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Abstract

Objective:

Neuropsychological impairment, including deficits in social cognition is evident in subjects at genetic high-risk for psychosis. However, findings in youth at genetic risk to bipolar disorder (BP) have been suggested to be less supportive of premorbid deficits. We aimed to conduct a meta-analysis of cognitive deficits in youth with familiar risk for bipolar disorder (FHR-BD).

Methods:

A novel meta-analysis of FHR-BD (mean age 10–25), including 18 studies (786 offsprings/siblings of patients with BD and 794 healthy controls), was conducted.

Results:

Both general cognition (d = 0.29, CI = 0.15–0.44) and social cognition (d = 0.23, CI = 0–0.45) were impaired in FHR-BD. In comparison to controls, FHR-BD had significant deficits in several cognitive domains, including visual memory (d = 0.35), verbal memory (d = 0.21), processing speed (d = 0.26) and sustained attention (d = 0.36). There was no significant difference between FHR-BD and controls in planning and working memory.

Conclusions:

Cognitive deficits are evident in individuals who are at genetic high-risk for developing BD. Neurodevelopmental abnormalities are likely playing a role not only in schizophrenia but also in BD.

Keywords

Bipolar disorderHigh-riskFamilialCognition
Type
Review
Information
European Psychiatry , Volume 44 , July 2017 , pp. 17 - 23
Copyright
Copyright © European Psychiatric Association 2017

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