Cell Metabolism
Volume 25, Issue 1, 10 January 2017, Pages 8-10
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(S)Pot on Mitochondria: Cannabinoids Disrupt Cellular Respiration to Limit Neuronal Activity

https://doi.org/10.1016/j.cmet.2016.12.020Get rights and content
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Classical views posit G protein-coupled cannabinoid receptor 1s (CB1Rs) at the cell surface with cytosolic Giα-mediated signal transduction. Hebert-Chatelain et al. (2016) instead place CB1Rs at mitochondria limiting neuronal respiration by soluble adenylyl cyclase-dependent modulation of complex I activity. Thus, neuronal bioenergetics link to synaptic plasticity and, globally, learning and memory.

Keywords

cannabinoid
cannabis
THC
endocannabinoid
cannabinoid receptor 1
mitochondrial import
GPCR
axonal growth
respiration
bioenergetics

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