Chemistry & Biology
Volume 18, Issue 9, 23 September 2011, Pages 1143-1152
ArticleA Systematic Family-wide Investigation Reveals that ∼30% of Mammalian PDZ Domains Engage in PDZ-PDZ Interactions
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Graphical Abstract
Highlights
► PDZ-PDZ interactions were investigated on a proteome-wide scale by combining the throughput of protein microarray technology with the fidelity of solution-phase fluorescence polarization ► Thirty-seven PDZ-PDZ interactions were identified, and a representative subset of these interactions was investigated biochemically and found to mediate protein-protein interactions in the context of their full-length proteins ► Overall, PDZ-PDZ dimerization was found to be a much more frequently used binding mode than was previously appreciated
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These authors contributed equally to this work
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Present address: Merrimack Pharmaceuticals, Inc., Cambridge, MA 02139, USA
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