Cell
Volume 143, Issue 5, 24 November 2010, Pages 694-702
Journal home page for Cell

Review
Pathogen-Mediated Posttranslational Modifications: A Re-emerging Field

https://doi.org/10.1016/j.cell.2010.11.019Get rights and content
Under an Elsevier user license
open archive

Posttranslational modifications are increasingly recognized as key strategies used by bacterial and viral pathogens to modulate host factors critical for infection. A number of recent studies illustrate how pathogens use these posttranslational modifications to target central signaling pathways in the host cell, such as the NF-kB and MAP kinase pathways, which are essential for pathogens' replication, propagation, and evasion from host immune responses. These discoveries open new avenues for investigating the fundamental mechanisms of pathogen infection and the development of new therapeutics.

Cited by (0)