Cell
Volume 118, Issue 1, 9 July 2004, Pages 2-4
Journal home page for Cell

Preview
Neddylating the Guardian: Mdm2 Catalyzed Conjugation of Nedd8 to p53

https://doi.org/10.1016/j.cell.2004.06.015Get rights and content
Under an Elsevier user license
open archive

Abstract

The tumor suppressor and transcriptional regulator p53 is perhaps one of the most regulated proteins in the cell nucleus and is acted upon by a variety of protein kinases, acetylases, ubiqutin ligases and hydrolases, and SUMO-conjugating enzymes. Now new work suggests a role for an additional modification—neddylation—in negative regulation of p53 transcriptional activity.

Cited by (0)