Cancer Cell
Volume 19, Issue 2, 15 February 2011, Pages 192-205
ArticleTumor-Derived Jagged1 Promotes Osteolytic Bone Metastasis of Breast Cancer by Engaging Notch Signaling in Bone Cells
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Graphical Abstract
Highlights
► Jagged1 promotes osteolytic bone metastasis by activating stromal Notch signaling ► Notch signaling induces IL-6 secretion from osteoblasts to stimulate tumor growth ► Jagged1 is an essential functional target of TGFβ in osteolytic bone metastasis ► GSI inhibits Jagged1-mediated bone metastasis by targeting stromal Notch signaling
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