Kojyl cinnamate ester derivatives promote adiponectin production during adipogenesis in human adipose tissue-derived mesenchymal stem cells
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Acknowledgments
This research was supported by and the National Research Foundation of Korea (NRF) Grant funded by the Ministry of Education, Science and Technology (Grant No. 2012012738).
References and notes (16)
- et al.
J. Am. Acad. Dermatol.
(1986) - et al.
J. Am. Acad. Dermatol.
(2005) - et al.
Biochem. Pharmacol.
(2009) Biochem. Pharmacol.
(2012)- et al.
Clin. Chim. Acta
(2005) - et al.
J. Dermatol. Sci.
(2012) - et al.
Arch. Pharmacal Res.
(2013) - et al.
Skin Res. Technol.
(2010)
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2018, Bioorganic and Medicinal ChemistryCitation Excerpt :Previously, we reported that a topical kojyl cinnamate ester derivative, 5-hydroxy-4-oxo-4H-pyran-2-yl-methyl (E)-3-(benzo[d][1,3]dioxol-5-yl)acrylate (also called as seletinoid G, 1), improved the mass balance of collagen in aged human skin.7 Compound 1 was designed for ameliorating skin aging phenotypes by achieving the prevention of gradual subcutaneous fat loss and the inhibition of the reactive oxygen species.9 The cinnamate moiety was identified to induce adipocyte differentiation in a natural product library screnning.9
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