9-Aminomethyl-9,10-dihydroanthracene (AMDA) analogs as structural probes for steric tolerance in 5-HT2A and H1 receptor binding sites
Graphical abstract
The synthesis, biological evaluation, and molecular modeling of dihydrotetracene/dihydrotetraphene and N-phenylalkyl analogs of AMDA as molecular probes of the ligand binding sites in 5-HT2A and H1 receptors is reported.
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Acknowledgments
This work was supported by United States Public Health Service Grant R01-MH57969 (R.B.W.), R01-MH61887 (B.L.R.) and the NIMH Psychoactive Drug Screening Program (B.L.R.).
References and notes (24)
- et al.
Bioorg. Med. Chem. Lett.
(2008) - et al.
Bioorg. Med. Chem. Lett.
(2001) - et al.
Bioorg. Med. Chem.
(2009) - et al.
Methods Neurosci.
(1995) - et al.
Bioorg. Med. Chem. Lett.
(2002) - et al.
Bioorg. Med. Chem.
(2005) - et al.
Bioorg. Med. Chem. Lett.
(2009) - et al.
- et al.
J. Mol. Biol.
(1997) - et al.
Annu. Rev. Med.
(2009)
Chem. Rev.
(2008)
Life Sci.
(2003)
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