Structural basis for the inhibitor recognition of human Lyn kinase domain

https://doi.org/10.1016/j.bmcl.2009.10.038Get rights and content

Abstract

Human Lyn tyrosine kinase is expressed in hematopoietic tissues and plays crucial roles in the signal transduction of hematopoietic immune system. Its excess activity is involved in several tumors. The crystal structure has revealed that the potent inhibitor staurosporine binds to human Lyn kinase domain at the ATP-binding site. The remarkable structural features of the staurosporine-binding region will offer valuable structural insights for the structure-based design of novel Lyn-selective inhibitors.

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Acknowledgments

The synchrotron radiation experiments were done at Photon Factory with the approval of the Japan Synchrotron Radiation Research Institute. We thank the staff for their help in data collection at the NW-12 station.

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