Biochemical and Biophysical Research Communications
Volume 469, Issue 3, 15 January 2016, Pages 587-592
The modeling of Alzheimer's disease by the overexpression of mutant Presenilin 1 in human embryonic stem cells
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open access
Keywords
Human embryonic stem cell
Alzheimer's disease
Cellular disease model
Presenilin 1
Synaptic dysfunction
Abbreviations
hPSC
human pluripotent stem cell
hESC
human embryonic stem cell
hiPSC
human induced pluripotent stem cell
AD
Alzheimer's disease
PS1
presenilin 1
Aβ
amyloid beta
ALS
amyotrophic lateral sclerosis
SOD1
superoxide dismutase 1
HPRT1
hypoxanthine phosphoribosyltransferase 1
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Current address. ReproCELL Inc., Yokohama, Kanagawa 222-0033, Japan.
Copyright © 2015 The Authors. Published by Elsevier Inc.