ReviewClassification of extrachromosomal circular DNA with a focus on the role of extrachromosomal DNA (ecDNA) in tumor heterogeneity and progression
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Keywords
eccDNA
Extrachromosomal DNA
Biogenesis
Oncogene amplification
Micronuclei
Tumor heterogeneity
Abbreviations
eccDNA
extrachromosomal circular DNA
spcDNA
small polydispersed DNA
bp
base pairs
t-circles
telomeric circles
ecDNA
extrachromosomal DNA
DMs
double minutes
ALT
alternative lengthening of telomeres
ORC
origin recognition complex
WRN
Werner syndrome protein
HSRs
homogeneously staining regions
GBM
glioblastoma
FISH
fluorescent in situ hybridization
DHFR
dihydrofolate reductase
MTX
methotrexate
EGFR
epidermal growth factor receptor
TKI
tyrosine kinase inhibitor
BFB
Breakage-fusion-bridge
HU
Hydroxyurea
HBV
hepatitis B virus
cccDNA
covalently closed circular DNA
ctDNA
circulating tumor DNA
Cited by (0)
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ZL and WJ contributed equally to this work.
© 2020 The Author(s). Published by Elsevier B.V.