Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Volume 1864, Issue 6, June 2017, Pages 1099-1120
ReviewCalcium, oxidative stress and connexin channels, a harmonious orchestra directing the response to radiotherapy treatment?
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Abbreviations
ADP
adenosine diphosphate
AMP
adenosine monophosphate
ATP
adenosine triphosphate
[Ca2+]i
intracellular calcium concentration
CaM
calmodulin
CaMKII
Ca2+/calmodulin-dependent kinase II
cAMP
cyclic adenosine monophosphate
COX-2
cyclooxygenase-2
Cx
connexin
EGFR
epidermal growth factor receptor
eNOS
endothelial nitric oxide synthase
ER
endoplasmic reticulum
ERK
extracellular signal-regulated kinase
GJC
gap junction channel
GPCR
G-protein coupled receptor
GRP75
glucose regulated protein 75
HMGB-1
high-mobility group box 1
IL
interleukin
iNOS
inducible nitric oxide synthase
IP3
inositol 1,4,5-trisphosphate
IP3R
inositol 1,4,5-trisphosphate receptor
MAPK
mitogen-activated protein kinase
mtDNA
mitochondrial DNA
mTOR
mammalian target of rapamycin
NADPH
nicotinamide adenine dinucleotide phosphate
NO
nitric oxide
nNOS
neuronal nitric oxide synthase
Panx
pannexin
PGE2
prostaglandin E2
PI3K
phosphatidylinositol 3-kinase
PKC
protein kinase C
PLC
phospholipase C
P2X7R
P2X7 receptor
RIBE
radiation-induced bystander effect
RNS
reactive nitrogen species
ROS
reactive oxygen species
RyR
ryanodine receptor
TNF-α
tumor necrosis factor-α
VDAC
voltage-dependent anion channel
Keywords
Ionizing radiation
Calcium
Oxidative stress
Connexin hemichannel
Gap junction
Bystander effect
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