Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Volume 1823, Issue 2, February 2012, Pages 465-475
Nucleo-cytoplasmic shuttling of PAK4 modulates β-catenin intracellular translocation and signaling
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Highlights
► PAK4 nuclear export is mediated by CRM-1-dependent pathway. ► PAK4 interacts with and phosphorylates β-catenin on Ser675. ► PAK4 phosphorylation of β-catenin on Ser675 promotes its transcriptional activity. ► Nuclear import of PAK4 accompanies with the nuclear import of β-catenin. ► PAK4 associates with the TCF/LEF transcriptional complex.
Keywords
PAK4
Nucleo-cytoplasmic shuttling
β-catenin
Signal transduction
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