Case ReportImmunoglobulin G4–associated inflammatory pseudotumor of urinary bladder: a case report
Introduction
Inflammatory pseudotumor (IPT) occurs commonly in the lung and occasionally in extrapulmonary organs such as urinary tract including the urinary bladder [1], [2], [3], [4]. Since the first description of IPT of the urinary bladder by Roth [5], multiple case reports and series have reported similar lesions under a variety of names such as fibroxanthoma, inflammatory myofibroblastic tumor, inflammatory myofibrohistiocytic proliferation, pseudosarcomatous fibromyxoid tumor, visceral form of nodular fasciitis, or plasma cell granuloma, suggesting it to be heterogeneous disease entity [1], [2], [4], [6], [7], [8], [9], [10]. The association between immunoglobulin (Ig) G4 dysregulation and IPT was first described in sclerosing pancreatitis [11]. Recently, some reports have suggested that a subset of IPT in various organs such as liver, breast, and lung can be associated with IgG4 abnormalities and was classified as an IgG4-associated IPT [10], [12], [13]. Inflammatory pseudotumor of the urinary bladder has been occasionally reported. However, IgG4-associated IPT of the urinary bladder has not been described to date. To the best of our knowledge, this is the first description of IgG4-associated IPT in the urinary bladder.
Section snippets
Case presentation
A 72-year-old Korean female patient presented with 4-month history of gross painless hematuria. She had no history of instrumentation and had no other symptoms. Physical examination findings on admission were essentially unremarkable. Hematologic tests showed anemia with hemoglobin level of 10.1 g/dL (reference range, 12-16 g/dL), and serum albumin was slightly low with 3.2 g/dL (reference range, 3.5-5.0 g/dL). Other blood chemistry values were within normal limits, and serum IgG was 1130.0
Methods
Clinical information was obtained from the review of the patient's medical records. Gross specimens and hematoxylin-eosin–stained slides were examined. Routinely processed, formalin-fixed, paraffin-embedded tissue sections were stained with hematoxylin and eosin. Immunohistochemical studies were performed for IgG4 (1:1000; Invitrogen, Calsbad, CA), IgG (1:1000; Novocastra, Newcastle Upon Tyne, UK), anaplastic lymphoma kinase (ALK) (1:50; Novocastra), and smooth muscle actin (SMA) (1:200;
Results
Pathologic examination of the partial cystectomy and segmental resection of the sigmoid colon revealed that the mass lesion, the epicenter in the bladder, was composed of haphazardly scattered spindle-shaped fibroblasts and myofibroblasts with occasional single prominent nucleolus without significant cytologic atypia or hyperchromatism in the background of highly vascularized myxoid stroma and prominent reactive lymphoid follicles, present in the entire layer of the bladder, particularly in the
Discussion
Inflammatory pseudotumor of the genitourinary tract is a rare lesion and most commonly involves the urinary bladder [1], [2], [3], [4], [8], [9]. The first IPT was described by Roth [5] in 1980 in a female patient presenting with recurrent cystitis. Nochomovitz and Orenstein [8] reported 2 cases of benign mesenchymal tumor arising in the urinary bladder with clinical diagnosis of sarcomas, which histologically resembled nodular fasciitis, and the authors called these lesions as IPT. Ro et al [9]
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