Clinical Communication to the EditorAnosmia Induced by Amiodarone
References (3)
Amiodarone: reevaluation of an old drug
Ann Intern Med
(1995)
Cited by (6)
The failure to detect drug-induced sensory loss in standard preclinical studies
2015, Journal of Pharmacological and Toxicological MethodsSniffing out pharmacology: Interactions of drugs with human olfaction
2012, Trends in Pharmacological SciencesCitation Excerpt :Consistent with the molecular pathways underlying drug effects on olfaction, loss of smell has been a frequent subject of anecdotal reports upon undesired drug effects. Such effects have been published regarding the calcium-channel blockers nifedipine [26] and diltiazem [27], the sodium- and potassium-channel blocker amiodarone [28], and topiramate, which acts at several ion channels [29]. Enzymes, and thus their inhibitors, also play a role in olfaction.
Positive inotropic drugs and drugs used in dysrhythmias
2010, Side Effects of Drugs AnnualCitation Excerpt :The authors calculated that the maximum possible annual incidences of bilateral visual loss in subjects taking amiodarone continuously for 4 to over 60 months in daily doses of >2.0 mg/kg (n = 696), >3.0 mg/kg (n = 559), or >4.0 mg/kg (n = 219) were 0.23%, 0.29%, and 0.74% respectively. Anosmia has been attributed to amiodarone in a 66-year-old man who took amiodarone 200 mg/day for 3 years; the symptom abated when the dosage was reduced to 100 mg/day (112A). There are two types of amiodarone-induced thyrotoxicosis: type 1 occurs in those with latent disease and is due to the iodine that amiodarone contains; type 2 is due to a destructive thyroiditis in a previously normal gland.
Antiarrhythmic drug-induced smell and taste disturbances: A case report and literature review
2018, Medicine (United States)Influence of drugs on smelling capacity. A review
2017, Flavour and Fragrance JournalDrugs and nutrition: How side effects can influence nutritional intake
2010, Proceedings of the Nutrition Society