American Journal of Obstetrics and Gynecology
Oral Plenary Session IIFriday, January 27 • 8:00 AM - 10:00 AM • Augustus Ballroom45: Long-term mortality risk and life expectancy following recurrent hypertensive disease of pregnancy
Section snippets
Objective
To determine whether women with recurrent hypertensive disease of pregnancy (HDP) have increased risk for early mortality and shorter life spans, and to determine the timing and most common causes of their deaths.
Study Design
We defined a cohort of births from 1939-2012 using the Utah Population Database. Using birth certificate data, we determined the number of pregnancies affected by HDP for each woman (0, 1, or >1). Exposed women had ≥1 singleton pregnancy complicated by HDP and lived in Utah for ≥1 year following delivery. Exposed women (with HDP) were matched 1:2 to unexposed women by age, year of childbirth, and parity at time of index pregnancy. Primary cause of death (COD) was determined from death
Results
We identified 57,384 women with at least one pregnancy complicated by HDP (49,598 women with 1 affected pregnancy and 7,786 women with >1 affected pregnancies). These exposed women were matched to 114,768 unexposed women. As of 2016, 11,894 women were deceased: 4,722 (8.2%) exposed and 7,172 (6.3%) unexposed. Recurrent HDP was significantly associated with an increased risk of all-cause mortality (aHR 2.04, 95% CI 1.76-2.36) as well as mortality due to diabetes (aHR 4.33, 95% CI 2.21-8.47),
Conclusion
Women with a history of HDP have increased mortality risk and decreased life expectancy compared to women without a history of HDP. This risk increases further with >1 pregnancy affected by HDP.