Selections from the 25th Annual Meeting of the Society for Maternal-Fetal Medicine, February 9-12, Reno, NevadaUrinary angiogenic factors cluster hypertensive disorders and identify women with severe preeclampsia
Section snippets
Participants and sample collection
We studied samples of urine from 68 women admitted at Yale New Haven Hospital between February and August 2004. Samples were collected under protocols approved by the Human Investigation Committee of Yale University. Written informed consent was obtained from all participants. Gestational age was established based on menstrual date and/or ultrasonographic examination before 20 weeks' gestation. All women solicited for enrollment in the study agreed to participate. We requested enrollment from
Characteristics of women
Out of 68 patients enrolled in this study, 17 met criteria for sPE. By study design, our patients were enrolled prospectively, so that at the time of enrollment we were aware only whether a subject is or is not hypertensive and proteinuric, and whether it meets or does not meet the clinical criteria for sPE. Because at the time of enrollment we could not precisely establish the nature of the hypertensive condition, the pHTN group (n = 21) was heterogeneous, consisting of women with mild
Comment
We found that urinary sFlt-1 and PlGF are altered in women with hypertensive disorders during pregnancy. We further observed that a ratio between the two functionally opposing angiogenic factors, sFlt-1 and PlGF, has high sensitivity and specificity in differentiating women with sPE from normotensive controls. Most importantly, we discovered that the ratios between sFlt-1 and PlGF could discriminate sPE from other forms of proteinuric hypertensive disorders, including mild preeclampsia with or
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2019, EClinicalMedicineCitation Excerpt :The technical validation analysis showed no difference between the two methods (appendix p 6). Levels of urine and serum soluble fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PlGF) were immunoassayed as previously described [10]. The sFlt-1/PlGF ratios were calculated and used for comparison with the results of the CRD Paper Test; details provided in the appendix (p. 5).
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Oral presentation at the 25th Annual Meeting of the Society for Maternal-Fetal Medicine, February 7-12, 2005, Reno, Nev.