Original articleAn association between central serous chorioretinopathy and gastroesophageal reflux disease☆
Section snippets
Patients and methods
Central serous chorioretinopathy was diagnosed in patients who had a neurosensory retinal detachment attributed to leakage from the level of the retinal pigment epithelium without evidence of other possible cause of exudation, such as inflammation, infiltration, or choroidal neovascularization.1 Patients were designated as having GERD if diagnosed and treated for the same by their primary care physicians. All records of patients with diagnosis of CSC who were seen in clinic from January 1,
Results
A total of 69 patients with CSC (cases) and 55 controls comprised the study population. The mean age of the CSC group was 46 years (SD = 10.6 years; range = 30–73 years). The mean age of the control group was 41 years (SD = 11.1 year; range = 18–61 years).
Of the 69 patients, 16 (vs 12 controls) used tobacco products, none (vs 1 control) used agents for weight loss, 12 (vs 5 controls) used antidepressant/antianxiety medications, none (vs 1 control) used amphetamines, 14 (vs 7 controls) used
Discussion
This study compared 68 consecutive patients known to have CSC with a historical control group to evaluate a clinically observed association between CSC and GERD. Several other known factors were examined to assess their significance in predisposing patients to developing CSC.
A significant association was found between CSC and GERD. Systemic lupus erythematosus, history of organ transplant, and hypertension have shown significance in other studies,1 but in this study none of these conditions was
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Support provided by Research to Prevent Blindness, New York, New York.