Guest Editorial

Accelerating the Translation of Artificial Intelligence From Ideas to Routine Clinical Workflow

Federated Learning (FL) has been foundational in improving the performance of a wide range of applications since it was first introduced by Google. Some of the most prominent and commonly used FL-powered applications are Android’s Gboard for predictive text and Google Assistant. FL can be defined as a setting that makes on-device, collaborative Machine Learning possible. A wide range of literature has studied FL technical considerations, frameworks, and limitations with several works presenting a survey of the prominent literature on FL. However, prior surveys have focused on technical considerations and challenges of FL, and there has been a limitation in more recent work that presents a comprehensive overview of the status and future trends of FL in applications and markets. In this survey, we introduce the basic fundamentals of FL, describing its underlying technologies, architectures, system challenges, and privacy-preserving methods. More importantly, the contribution of this work is in scoping a wide variety of FL current applications and future trends in technology and markets today. We present a classification and clustering of literature progress in FL in application to technologies including Artificial Intelligence, Internet of Things, blockchain, Natural Language Processing, autonomous vehicles, and resource allocation, as well as in application to market use cases in domains of Data Science, healthcare, education, and industry. We discuss future open directions and challenges in FL within recommendation engines, autonomous vehicles, IoT, battery management, privacy, fairness, personalization, and the role of FL for governments and public sectors. By presenting a comprehensive review of the status and prospects of FL, this work serves as a reference point for researchers and practitioners to explore FL applications under a wide range of domains.

To show that a deep learning (DL)–based, automated model for Lipiodol (Guerbet Pharmaceuticals, Paris, France) segmentation on cone-beam computed tomography (CT) after conventional transarterial chemoembolization performs closer to the “ground truth segmentation” than a conventional thresholding-based model.

This post hoc analysis included 36 patients with a diagnosis of hepatocellular carcinoma or other solid liver tumors who underwent conventional transarterial chemoembolization with an intraprocedural cone-beam CT. Semiautomatic segmentation of Lipiodol was obtained. Subsequently, a convolutional U-net model was used to output a binary mask that predicted Lipiodol deposition. A threshold value of signal intensity on cone-beam CT was used to obtain a Lipiodol mask for comparison. The dice similarity coefficient (DSC), mean squared error (MSE), center of mass (CM), and fractional volume ratios for both masks were obtained by comparing them to the ground truth (radiologist-segmented Lipiodol deposits) to obtain accuracy metrics for the 2 masks. These results were used to compare the model versus the threshold technique.

For all metrics, the U-net outperformed the threshold technique: DSC (0.65 ± 0.17 vs 0.45 ± 0.22, P < .001) and MSE (125.53 ± 107.36 vs 185.98 ± 93.82, P = .005). The difference between the CM predicted and the actual CM was 15.31 mm ± 14.63 versus 31.34 mm ± 30.24 (P < .001), with lesser distance indicating higher accuracy. The fraction of volume present ([predicted Lipiodol volume]/[ground truth Lipiodol volume]) was 1.22 ± 0.84 versus 2.58 ± 3.52 (P = .048) for the current model’s prediction and threshold technique, respectively.

This study showed that a DL framework could detect Lipiodol in cone-beam CT imaging and was capable of outperforming the conventionally used thresholding technique over several metrics. Further optimization will allow for more accurate, quantitative predictions of Lipiodol depositions intraprocedurally.