ArticleAurora kinase B, epigenetic state of centromeric heterochromatin and chiasma resolution in oocytes
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Ursula Eichenlaub-Ritter has been Professor for Cell Biology at the University of Bielefeld, Department of Gene Technology/Microbiology since 1991. Her major interests are in the development of non-invasive methods to assess oocyte and embryo quality, and regulation of gene expression, spindle formation and cell cycle control at mammalian oogenesis, and in reproductive toxicology and stem cell research.
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Cited by (39)
Specialize and Divide (Twice): Functions of Three Aurora Kinase Homologs in Mammalian Oocyte Meiotic Maturation
2017, Trends in GeneticsCitation Excerpt :The AURKB antibodies that detect AURKB in somatic cells may not be sensitive enough to routinely detect AURKB in mammalian gametes, making examination of the endogenous protein localization difficult [14,41]. However, some groups have successfully detected AURKB by immunocytochemistry and western blotting [14,42]. These results are consistent with the presence of Aurkb transcripts in mouse oocytes [43] as well as with the presence of the protein in human oocytes and embryos [13,44–46].
Targeting the interaction of Aurora kinases and SIRT1 mediated by Wnt signaling pathway in colorectal cancer: A critical review
2016, Biomedicine and PharmacotherapyCitation Excerpt :During prophase, the Aurora B kinase localize first to the nucleus then to the inner midzone of the spindle and peaks in G2/M phase, where the maximum kinase activity has reached at metaphase [32]. It controls the proper microtubule-kinetochore attachment and maintenance of later phosphorylation state of CENP-A, includes accurate chromosome segregation, bi-orientation, assembly of the mitotic spindle, proper microtubule-kinetochore attachment, protein localization, regulation of mitotic checkpoint and cytokinesis in mitosis (Fig. 1) [33]. It also senses the errors in kinetochores to microtubules attachment may cause merotelic (one kinetochore attached to microtubules from both sides) or syntelic attachment (both sister kinetochore attached to microtubules from the same pole), which delaying the anaphase signal to activate the mitotic checkpoint (amphiletic) [34].
Aurora B inhibitor barasertib prevents meiotic maturation and subsequent embryo development in pig oocytes
2015, TheriogenologyCitation Excerpt :A study in Spisula oocytes reported that inhibition of Aurora B kinase activity lead to chromatin decondensation, chromosome segregation defects, and inhibits polar body formation [17]. Recently, several studies in mouse oocytes reported that suppression of Aurora B activity with ZM447439 resulted in most oocytes being arrested at the MI, with improperly condensed and misaligned chromosomes, as well as abnormal spindles [19,20,34]. Consistent with previous reports, our results also show that Aurora B inhibition in porcine oocytes resulted in significantly higher percentages of the barasertib-treated oocytes with aberrant spindles and misaligned chromosomes, and it blocked the cell-cycle progression to the MI stage.
Chronic exposure to a low concentration of bisphenol A during follicle culture affects the epigenetic status of germinal vesicles and metaphase II oocytes
2013, Fertility and SterilityCitation Excerpt :Further studies are required to support this notion. We and others found previously that alterations in the epitope of histone H3 at residues 9 and 10 are associated with spindle aberrations, chromosomal misalignment, and congression failures in mouse MII oocytes (54–56). Accessibility of the epitope recognized by antibody to trimethylated H3 lysine 9 does not appear to be affected by serine 10 phosphorylation status (57).
Overexpression of Aurora Kinase B Is Correlated with Diagnosis and Poor Prognosis in Hepatocellular Carcinoma
2024, International Journal of Molecular SciencesThe evaluation of effect of aurora kinase inhibitor cct137690 in melanoma and melanoma cancer stem cell
2021, Anti-Cancer Agents in Medicinal Chemistry
Ursula Eichenlaub-Ritter has been Professor for Cell Biology at the University of Bielefeld, Department of Gene Technology/Microbiology since 1991. Her major interests are in the development of non-invasive methods to assess oocyte and embryo quality, and regulation of gene expression, spindle formation and cell cycle control at mammalian oogenesis, and in reproductive toxicology and stem cell research.
Preliminary results of the study were presented at the 7th Biennial Conference of ALPHA (Scientists in Reproductive Medicine) in Istanbul, 2008, and at the 24th Annual Meeting of the European Society of Human Reproduction and Embryology (ESHRE) in Barcelona, 2008.
Declaration: The authors report no financial or commercial conflicts of interest.