Original reportBlood pressure and heart rate: No evidence for a positive association with prostate cancer☆
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A role for cAMP-driven transactivation of EGFR in cancer aggressiveness - Therapeutic implications
2014, Medical HypothesesCitation Excerpt :Obesity/metabolic syndrome, tobacco use, and lack of exercise can all raise the pulse rate [119–121] while also increasing cancer risk and mortality [122–124]; the fact that heart rate persists as a determinant of cancer mortality after statistical adjustment for these factors is consistent with the thesis that sympathetic drive per se increases risk for cancer death, and may in fact mediate, in part, the increased cancer risk associated with metabolic syndrome, smoking, and sedentary lifestyle. Prospective analyses examining prostate cancer specifically have concluded that heart rate correlates positively with prostate cancer incidence [125] and mortality [126], albeit one study could not confirm such a relationship [127]. Inasmuch as most of these studies deal with cancer mortality – as opposed to incidence – they do not clarify to what extent an impact on cancer prognosis may have played a role in the higher cancer mortality observed with high pulse rate.
Constitutional risk factors in prostate cancer
2011, Actas Urologicas EspanolasHypertension, heart rate, use of antihypertensives, and incident prostate cancer
2001, Annals of EpidemiologyPositive association between resting pulse and cancer incidence in current and former smokers
1999, Annals of EpidemiologyResting heart rate as a predictor of cancer mortality: A systematic review and meta-analysis
2021, Journal of Clinical Medicine
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This work was supported by grant no. R35 CA94761 from the National Cancer Institute.