G protein-coupled receptor structure and function: The impact of disease-causing mutations
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The Principles, Enzymes, and Pathways of Human Steroidogenesis
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2014, Cellular Endocrinology in Health and DiseaseCalcium sensing receptor signalling in physiology and cancer
2013, Biochimica et Biophysica Acta - Molecular Cell ResearchCitation Excerpt :Such models can facilitate interpretation of experimental data, obtained for instance with FRET measurements of G-protein activation, and support molecular understanding of the altered behaviour of wild-type vs. mutated cooperative proteins [23,144,158–160]. Several studies on GPCRs concluded that the Monod–Wyman–Changeux (MWC) model of cooperative proteins applies to membrane receptors, e.g. GPCRs [155,161–163]. The cooperativity between subunits of the CaSR suggests that the MWC model would be suitable to describe the CaSR.
The Principles, Enzymes, and Pathways of Human Steroidogenesis
2010, Endocrinology: Adult and Pediatric, Sixth EditionConstitutive activation of G protein-coupled receptors and diseases: Insights into mechanisms of activation and therapeutics
2008, Pharmacology and TherapeuticsConstitutive activity and inverse agonism at the α<inf>1</inf>adrenoceptors
2007, Biochemical PharmacologyCitation Excerpt :The discovery of the constitutively active mutants (CAMs) in the AR family catalyzed the interest of a large number of groups towards the elucidation of two main aspects of GPCR function and drug action: (a) the activation process of GPCRs and (b) the identification of ligands with negative efficacy. In addition, the discovery of the CAM GPCRs encouraged the search for spontaneously occurring activating mutations of different receptors which are responsible for a number of human diseases [16]. This article will briefly review some of the findings obtained in the last several years on constitutive activity of the α1adrenoceptor subtypes and its implications on our understanding of inverse agonism.