Review articleVitamin A homeostasis and diabetes mellitus☆
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Cited by (68)
All-trans retinoic acid ameliorates glycemic control in diabetic mice via modulating pancreatic islet production of vascular endothelial growth factor-A
2016, Biochemical and Biophysical Research CommunicationsCitation Excerpt :Vitamin A is an essential component for maintaining immune tolerance and T-cell-mediated immunity [7,8]. Therefore, impaired vitamin A metabolism can affect the autoimmune response and development of T1DM [9]. Several clinical studies showed that the individuals with T1D had decreased circulating levels of vitamin A or RBP4 as compared to the non-diabetics [10–12].
Role of vitamin A in type 2 diabetes mellitus biology: Effects of intervention therapy in a deficient state
2015, NutritionCitation Excerpt :The complexity of vitamin A intake is highlighted by the fact that although vitamin A supplementation altered the risk for and outcomes of acute respiratory tract infections in third-world countries; an adverse effect was observed when administered to children in developed countries [56]. In certain cases, it has been observed that vitamin A metabolism affected during the onset of diabetes is not reversed by vitamin A supplementation alone [57]. In streptozotocin-induced diabetes in rats, it was found that vitamin A supplementation could not elevate the serum vitamin A levels, rather hepatic levels of retinol were found to be increased ultimately resulting in hepato-toxicity.
Protection from diabetic cardiomyopathy — Putative role of the retinoid receptor-mediated signaling
2013, Journal of Molecular and Cellular CardiologyThe Membrane Receptor for Plasma Retinol-Binding Protein, A New Type of Cell-Surface Receptor
2011, International Review of Cell and Molecular BiologyCitation Excerpt :In addition to vision, known biological functions of vitamin A include its roles in embryonic growth and development, immune competence, reproduction, maintenance of epithelial surfaces, and proper functioning of the adult brain (Drager, 2006; Duester, 2008; Mangelsdorf et al., 1993; Napoli, 1999; Ross and Gardner, 1994). Since vitamin A derivatives have profound effects on cellular growth and differentiation, vitamin A also plays positive or negative roles in a wide range of pathological conditions, such as visual disorders (Travis et al., 2006), cancer (Love and Gudas, 1994; Niles, 2004; Verma, 2003), infectious diseases (Stephensen, 2001), diabetes (Basu and Basualdo, 1997; Yang et al., 2005), teratogenicity (Nau et al., 1994), and skin diseases (Chivot, 2005; Orfanos et al., 1997; Zouboulis, 2001). Except for vision, which depends on the aldehyde form of vitamin A, most of these physiological or pathological functions can be ascribed to retinoic acid's effects on nuclear hormone receptors (Chambon, 1996; Evans, 1994).
Alterations in Vitamin A/retinoic acid homeostasis in diet-induced obesity and insulin resistance
2017, Proceedings of the Nutrition Society
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Supported by The Natural Sciences and Engineering Research Council of Canada.