Patterns of bcl-2 expression in placenta
References (17)
- et al.
Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2limmunoglobulin transcript resulting from the t(14:18) translocation
Cell
(1986) Immunology of pregnancy: towards a unifying hypothesis
Eur J Obstet Gynecol Reprod Biol
(1992)- et al.
C-jun and jun-B oncogene expression during placental development
Am J Obstet Gynecol
(1991) - et al.
Differential gene expression in the amnion, chorion, and trophoblast of the human placenta
Placenta
(1993) - et al.
Cmyc and tumor suppressor gene product expression in developing and term trophoblast
Placenta
(1994) Bcl-2 breathes life into embryogenesis
Am J Pathol
(1994)- et al.
Expression of c-myc and c- f ms oncogenes in trophoblastic cells in hydatidiform mole and normal human placenta
J Clin Pathol
(1993) Placental pathology: A contemporary approach
Obstet Gynecol Ann
(1985)
Cited by (41)
Treatment of Lipoxin A<inf>4</inf> and its analogue on low-dose endotoxin induced preeclampsia in rat and possible mechanisms
2012, Reproductive ToxicologyCitation Excerpt :The Bcl-2 gene family, isolated from a B-cell lymphoma, includes apoptosis-promoting (Bax) and apoptosis-inhibiting (Bcl-2 and Bcl-x) members. Bcl-2 has been immunolocalized to the syncytiotrophoblast of the chorionic villi, persisting from the first to the third trimester of pregnancy but decreases as gestation progresses [50,51]. According to our results, LXA4 might exert its anti-apoptotic effect in vitro by up-regulating anti-apoptotic Bcl-2 and down-regulating pro-apoptotic Bax.
Cytotoxic Effect of Zinc-Citrate Compound on Choriocarcinoma Cell Lines
2007, PlacentaCitation Excerpt :Bcl-2 gene is a major regulator of apoptosis. It is known to inhibit apoptosis [27] and may be one of the maturation-related markers of trophoblasts which shows decreased expression along with terminal differentiation and maturation [28]. The Bax to Bcl-2 ratio is a important life and death regulator for cells and this regulation is influenced by competitive dimerization between two proteins [29].
Changes in apoptosis and Bcl-2 expression in human hyperglycemic, term placental trophoblast
2006, Diabetes Research and Clinical PracticeThe granzyme B inhibitor, PI-9, is differentially expressed during placental development and up-regulated in hydatidiform moles
2006, PlacentaCitation Excerpt :Although syncytial trophoblasts are a known immune privileged cell type, it is unclear why these cells do not express high levels of PI-9 until the later stages of pregnancy. However, it is interesting to note that other molecules of immune privilege such as HLA-G, Bcl-2 and FasL are also predominantly expressed by villous cytotrophoblasts and EVT, rather than the syncytial trophoblast layer [22,25–27]. Perhaps other protective mechanisms used by these cells are sufficient to combat any NK/CTL they may encounter in the maternal blood space.
Fetal growth restriction is associated with increased apoptosis in the chorionic trophoblast cells of human fetal membranes
2005, PlacentaCitation Excerpt :One mechanism for reduced placental size in FGR may be increased apoptosis (programmed cell death) [14]. The process of apoptosis, which was first described by Kerr et al. [15], has been identified in the human placenta [16,17]. Smith et al. [18] and Mayhew et al. [19] described apoptosis in placenta throughout normal pregnancies, predominantly in the villous trophoblast suggesting it as a normal placental process.
Caffeine suppresses the expression of the Bcl-2 mRNA in BeWo cell culture and rat placenta
2004, Journal of Nutritional Biochemistry
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Chong Jai Kim, MD, Department of Pathology, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul, 110-799, Korea