c-fos expression in superficial dorsal horn of cervical spinal cord associated with spontaneous scratching in rats with dry skin
Section snippets
Acknowledgements
This study was supported by grants from the California Tobacco-Related Disease Research Program (#6RT-0231 and 11RT-0053) and NIH (NS 35788 and DE 13685).
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5.48 - Itch: Preclinical to Clinical
2020, The Senses: A Comprehensive Reference: Volume 1-7, Second EditionNonsteroidal, Nonimmunosuppressive Therapies for Pruritus
2013, Veterinary Clinics of North America - Small Animal PracticeCitation Excerpt :Water evaporating off the skin dries it out and can lead to an increase in pruritus. This evaporation has been demonstrated in people38 and probably occurs in dogs as well. Maintaining a shorter hair coat will help to ensure that the skin and coat will be thoroughly dried after each bath.
Mouse model of touch-evoked itch (alloknesis)
2012, Journal of Investigative DermatologyCitation Excerpt :Between-group comparisons of counts of scratch bouts or alloknesis scores were made by unpaired t-test with P<0.05 considered to be significant. To induce chronic dry skin on the nape of the neck, we followed a previously reported procedure (Miyamoto et al., 2002; Nojima et al., 2003; Akiyama et al., 2010b). Briefly, a mixture of acetone and diethylether (1:1) was applied to a circumscribed area (approximately 15 × 15 mm2 spanning the midline) at the nape of the neck for 15 seconds, followed immediately by applying distilled water for 30 seconds, twice daily for a maximum of 12 days (designated as AEW treatment).
Spontaneous itch in the absence of hyperalgesia in a mouse hindpaw dry skin model
2010, Neuroscience LettersNalfurafine prevents 5′-guanidinonaltrindole- and compound 48/80-induced spinal c-fos expression and attenuates 5′-guanidinonaltrindole-elicited scratching behavior in mice
2009, NeuroscienceCitation Excerpt :While histamine activated neurons towards the inner side of lamina II, SLIGRL-NH2 and mosquito allergen activated neurons located more towards the outer side of the dorsal horn of lamina II. Similar to our results, stimulation of the group of neurons located on the lateral side of the superficial layer of the dorsal horn was also associated with 5-HT- (Nojima et al., 2003b) and dry skin- (Nojima et al., 2003a) induced scratching in rats. These results suggest that different pruritogens stimulate different neuron groups in the dorsal horn.