Elsevier

Neuroscience Letters

Volume 335, Issue 3, 2 January 2003, Pages 151-154
Neuroscience Letters

Relationship between musculoskeletal symptoms and blood markers of oxidative stress in patients with chronic fatigue syndrome

https://doi.org/10.1016/S0304-3940(02)01058-3Get rights and content

Abstract

In 21 patients with chronic fatigue syndrome (CFS) versus 20 normal subjects, we investigated the oxidant/antioxidant balance and its correlation with muscle symptoms. Patients versus controls showed significantly: lower Lag Phase and Vitamin E (Vit E) concentrations in plasma and low-density lipoproteins (LDL), higher LDL thiobarbituric acid reactive substances (TBARS), higher fatigue and lower muscle pain thresholds to electrical stimulation. A significant direct linear correlation was found between fatigue and TBARS, thresholds and Lag Phase, thresholds and Vit E in plasma and LDL. A significant inverse linear correlation was found between fatigue and Lag Phase, fatigue and Vit E, thresholds and TBARS. Increased oxidative stress and decreased antioxidant defenses are related to the extent of symptomatology in CFS, suggesting that antioxidant supplementation might relieve muscle symptoms in the syndrome.

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    Although the etiology of this disease is still unknown, recent studies have indicated the implication of oxidative stress, mitochondrial dysfunction and inflammation in the pathophysiology of FM [213,214]. For instance, different studies have observed increased oxidative stress and deregulated antioxidative parameters in patients with FM [37,213,215], events that have been associated with musculoskeletal manifestations like fatigue and pain [216]. Likewise, levels of altered lipid peroxidases were correlated with clinical symptoms and severity of FM [213].

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